Shields David E, Aclan Jennifer, Szatkowski Aaron PEER-REVIEWED, STABILITIES, COMPATIBILITIES, NEUROLOGY, STORAGEĬhemical Stability of Admixtures Combining Ziconotide with Fentanyl or Sufentanil During Simulated Intrathecal Administration The extended shelf-life allows the preparation to be readilyĬeline Corman, MSc, BSc, stability, compatibility, atropine sulfate, concentrated solution, antidote, nerve agents, David E.
Concentrated solutions of atropine sulfate can be compounded quicklyĪnd easily by using commercially available pharmaceutical-grade powder as theĪctive ingredient. The solutions were physically compatibleĪnd chemically stable when stored for 28 days at 35☌ and exposed to light,ģ64 days at 23☌ and exposed to light, or 364 days at 5☌ and protected from The potency of theĪtropine sulfate solution remained above the United States Pharmacopeia limit All solutions remained clear and colorless,Īnd the pH changed only slightly over the study period. The preparation was determined by using a stability-indicating high-performance Assessment of physical stability under several storageĬonditions was based on clarity, color, and pH monitoring. In isotonic saline solution and packaged in polypropylene syringes, which were Was developed using pharmaceutical-grade powder. A formulation for concentrated atropine sulfate solution (2 mg/mL)
A preparation of concentrated atropine for injectionįrom atropine powder is the ideal solution, but the stability of this preparation is Number of ampules needed for treatment, and the large volume of medication In using the commercial product are the time required to break the large Stockpiling of atropine in forms currently availableĬommercially can be costly and can require a large storage area. Issue: Nov/Dec 2008 - Arthritis and Immunological DiseasesĪbstract: Atropine is one of the preferred antidotes for nerve gas exposure. Physical Compatibility and Chemical Stability of a Concentrated Solution of Atropine Sulfate (2 mg/mL) for Use as an Antidote in Nerve Agent CasualtiesĪuthor(s): Donnelly Ronald F, Corman Celine
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